Claudia L. Kleinman
Department of Human Genetics, Faculty of Medicine
Karine is studying a Pol III-related leukodystrophy, which is a rare neurodegenerative disease caused by mutations in genes encoding subunits of RNA polymerase III. She is using RNA-Seq and ChIP-Seq in patient tissue, mouse and cellular models to assess the impact of the mutations on transcription. This will lead to a better understanding of the mechanisms leading to this devastating disease.
Nicolas De Jay
Using NGS technology and bioinformatics tools, Nicolas is trying to find transcriptomic and epigenetic alterations that could drive paediatric and embryonic brain tumours. To this end, he is simultaneously developing an RNAseq pipeline and using it to analyze NGS data.
Maud aims to identify biomarkers of therapeutic resistance in patients with metastatic colorectal cancer (mCRC). To this end, genome-scale analysis (including RNA-seq, miRNA-seq, exome-seq and DNA copy number) was performed in liver metastatic tissues pre and post chemotherapy treatment. Integrative analysis of these data should lead to the discovery of a molecular signature for therapeutic resistance in mCRC patients.
BSc Student, Joint Honours, Computer science & Biology
Selin is investigating how epigenetic modifications and changes in chromatin structure regulate brain development. She is working on a computational tool, chromswitch, to identify chromatin state switches in the developing brain from epigenomic data.
Research Assistant in Bioinformatics
Steven works on many projects, implementing and adding new features in our in-house pipelines. On top of that, he is our jack-of-all-trades data analyst for data derived from NGS platforms (i.e. DNAseq, RNAseq and smRNAseq).
PhD, Visiting Scientist
Jordan Prince Tremblay
BSc Computer Engineering, Summer Student